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If additional glycemic control is needed , increase the dosage to 2 mg once weekly after at least 4 weeks on the 1 mg dosage

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Pharmacodynamics: KPV is a melanocortin-derived tripeptide that regulates immune activity by inhibiting NF-B signaling and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

It restores normal nerve function and supports red blood cell production by correcting Vitamin B12 deficiency

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RESULTS The AnglV analog D~Nle-Tyr-Ile-NH-(CH 2 ) 5-CONH2 is more metabolically stable than Norleual (Nle-Tyr-Leu^-(CH 2 -NH 2 f- 4 -His-Pro~Phe (SEQ ID NO: 1) The AnglV-related peptidomimetic Norleual was previously shown to possess, anti- HGF/Met, anti-angiogenic, and anti-cancer activities